阿司匹林与华法林联用在大鼠体内的药效学实验

aggregation rate,prothrombin time and international normalized ratio,platelet intracellular [Ca2 i.Results:SD rats by gavage for 7daysafter abdominal aortic blood collection for determination of plateletaggregation function:blank group,inhibition of platelet aggregationrate 0.5%,single use of warfarin group platelet aggregation inhibitionrate 23%,aspirin plus warfarin group inhibition of platelet aggregationrate was 58%,there was significant difference between three groups,P<0.05;prothrombin time and the international normalized ratio:blankgroup16.7s prothrombin time,international normalized ratiol.04;singlewarfarin group20.Is prothrombin time,international normalized ratiol.42;aspirin plus warfarin group23.8s prothrombin time,internationalnormalized ratiol.67,three groups had a significant difference,P<0.05.Platelet cytosolic [Ca2"]I determination:blank group of plateletcytosolic [Ca"]I (57.6+13.1)nmol /L;single warfarin group of plateletcytosolic [Ca2]I (43.4 +12.5)nmol L;aspirin plus warfarin group ofplatelet cytosolic [Ca"]I (32.6 +11.3)nmol /L,there was significantdifference between three groups,P<0.05.Conclusion:aspirin andwarfarin anticoagulation effect of Lin Lian is better than that of thewarfarin group,can be used for coagulation function in severehyperparathyroidism,single use of warfarin in patients unable toeffectively control,can obtain good anticoagulant effect,but alsoshould pay attention to two to be combined with the bleeding tendency,in the practical application of the specific circumstances choice of drugcompatibility.Keywords:Aspirin Warfarin华法林是一种临床常用的香豆素类口服抗凝药，通过抑制肝脏的羧基化酶的作用，使维生素K依赖的部分凝血因子保持在其无活性的前体状态·，同时，华法林还可以诱导肝脏主动产生无活性的凝血因子前提，从而抑制凝血，发挥抗凝作用。阿司匹林主要抑制血小板的活性，还有一定的抗血栓的作用。其作用机制