何首乌的化学成分、药理作用及临床应用的研究进展

何首乌的化学成分、药理作用及临床应用的研究进展目录摘要4Abstract......…4引言.61何首乌的化学成分及药理作用..…61.1蒽醌类071.1.1抗肿瘤作用71.1.2抗炎和免疫调节作用>1.1.3抗菌作用....…81.2二苯乙烯苷类81.2.1抗氧化和抗衰老..81.2.2防治动脉粥样硬化..…91.2.3防治骨质疏松.101.2.4抗痴呆改善学习记忆101.2.5护肝功能..111.3黄酮类.111.3.1延缓衰老.121.3.2抗疲劳121.4萘醌类121.5磷脂类..121.6其他类.1.7何首鸟的中医药作用.132何首乌的炮制减毒作用...…142.1何首鸟的炮制.....2.2何首鸟的肝毒性....3何首鸟的临床应用.…153.1高血脂症153.2脱发.153.3高血压…163.4白癜风.……163.5润肠通便.….163.6其他临床应用174总结与展望.…17参考文献18致谢.….211摘要何首鸟作为一种传统的中药材，在中医药领域方面的使用历史悠久，本文从何首鸟的化学成分、药理作用及临床应用方面对何首鸟这一药材进行了比较全面的叙述，还对何首乌及炮制品的相关功效进行了相应的描述。何首鸟的入药部位是它的干燥块根，不同的炮制工艺对何首乌的药理作用会产生不同的影响，比如制用的何首鸟有补益精血的作用，而生品何首鸟则具有润肠通便的作用。经研究发现，何首鸟中含有丰富多样的化学成分，这些成分是何首鸟表现出独特治疗功效的基础，在这些成分当中，黄酮类化合物、蒽醌类化合物以及二苯乙烯苷等化合物的疗效尤其突出，它们使何首乌具有调节血脂、保护肝脏、抵御氧化等的药理作用，并且疗效显著，但在服用何首鸟的同时也应该密切关注肝毒性方面的问题。深入地了解何首乌的临床应用以及目前临床方面的研究进展，有利于更进一步推进何首乌的研究发展并为何首鸟的临床合理应用提供相应的依据。关键词：何首鸟：药理作用：化学成分：临床应用：功效AbstractPolygonum multiflorum,as a traditional Chinese medicinal herb,has a long history of usein the field of traditional Chinese medicine.This article provides a comprehensive account ofPolygonum multiflorum from the aspects of its chemical composition,pharmacological effects,and clinical applications.It also describes the related efficacy of Polygonum multiflorum and itsprocessed products.The medicinal part of Polygonum multiflorum is its dried root.Differentprocessing techniques have different effects on the pharmacological effects of Polygonummultiflorum.For example,processed Polygonum multiflorum has the effect of tonifyingessence and blood,while raw Polygonum multiflorum has the effect of moistening theintestines and promoting defecation.Through research,it has been found that Polygonummultiflorum contains a rich variety of chemical components.These components are the basisfor Polygonum multiflorum to exhibit unique therapeutic effects.Among these components,2flavonoids,anthraquinones,and stilbenoids have particularly prominent therapeutic effects.They make Polygonum multiflorum have pharmacological effects such as regulating bloodlipids,protecting the liver,and resisting oxidation,and the therapeutic effects are remarkable.However,when taking Polygonum multiflorum,one should also pay close attention to the issueof liver toxicity.In-depth understanding of the clinical application of Polygonum multiflorumand the current research progress in clinical aspects is conducive to further promoting theresearch and development of Polygonum multiflorum and providing corresponding basis for itsrational clinical application.Key Words:Polygonum multiflorum;Pharmacological effects;Chemical components;Clinical applications Efficacy3