金花清感颗粒联合奥司他韦治疗儿童流感的临床观察

金花清感颗粒联合奥司他韦治疗儿童流感的临床观察摘要目的：观察金花清感颗粒和奥司他韦联合治疗儿童流感的临床效果。方法：对河北省儿科呼吸科住院的小儿流行性感冒的病例进行回顾性分析。并对不同年龄的儿童甲流患者的临床特点进行了总结，并对其进行了临床意义的分析。本课题将采集流感患儿确诊病例700例，将其随机分成两组，一组采用奥司他韦，另一组采用金花清感颗粒与奥司他韦。检测两组人群中L-17、FN-y和NO的含量。结果：治疗组与对照组相比，治疗效果更好(P<0.01):治疗组的总体反应率及V转阴率（流感转阴率）高于对照组(P<0.05):治疗结束后，治疗组儿童血清中L-17的含量[(21.39±2.84)ngml]低于对照组明显降低，血清IFN-y和N0水平[(43.12±1.93)pg/ml和(37.88±2.32)molL]均高于对照组[(36.74士1.86)pgml和(30.96±2.19)umo/L],差异均有统计学意义(=11.061、19.448、16.831及15.337,均P<0.05)；观察组不良症状总体发生率为20%，与对照组的40%相比有显著性差异(x2=0.182,P=0.393,P>0.05)。结论：金花清感颗粒与奥司他韦颗粒联用治疗儿童流感疗效明显，能加速患儿病情的好转、缓解时间缩短、恢复快、病程短、复发少、不良反应发生率低，有很高的临床应用价值。关键词：金花清感颗粒：奥司他韦；儿童；流感ABSTRACTObjective:To apply Jinhua Qinggan Granules combined with oseltamivir in the treatment ofinfluenza virus infection in children and observe its improvement effect on clinical symptomsand signs in children.Method:A retrospective analysis of the clinical data of children withinfluenza treated in the respiratory department of Hebei Children's Hospital.To summarize andanalyze the clinical significance of relevant indicators by comparing the clinical characteristicsof different age groups of children with swine flu.In this study,a total of 700 confirmed cases ofinfluenza in children.Children were randomly assigned to the control group and the observationgroup,with 350 patients per group.Patients in the control group received oseltamivirtreatment,and those in the control group received oseltamivir.Detection of serum interleukin-17(IL-17),Creactive protein y Interferon (IFN-y)and the level of nitric oxide (NO).Result:Thetreatment group had a better treatmeat effect compared to the control group(P<0.01);The totaleffective rate and the negative conversion rate of IVA were higher in the control group (P<0.05);After treatment,the serum IL17 in the observation group of children [(21.39+2.84)ng/mlwas lower than that of the control group [(27.52+2.70)ng/ml,serum IFN-Y.And NO levels[(43.12+1.93)pg/ml and (37.88+2.32)umol/L was higher than that of the control group(36.74+1.86)pg/ml and (30.96+2.19)umol/L],the differences were statistically significant(t=11.061,19.448,16.831 and 15.337,average P<0.05);The overall rate of adverse symptomswas 20%in the control group (x2=0.182,P-0.393,P >0.05).Conclusion:The clinical efficacy ofoseltamivir granules in the adjuvant treatment of children with influenza is significant,which isconducive to accelerating the improvement of children's clinical symptoms,shortening the timeof symptom relief,promoting the recovery of the disease,shortening the course ofdisease,reducing the recurrence of the disease,and reducing the incidence of adverse symptoms.Ithas high clinical application value.Key Words:Jinhua Qinggan Granules;Ostavir;Children;InfluenzaⅡ目录第1章引言....第2章资料与方法32.1一般资料2.2方法.32.2.1治疗方法.32.2.2评价指标..32.3观察指标2.4统计学分析4第3章结果，3.1症状缓解时间及病程比较.53.2体温恢复时间…。.53.3两组患儿治疗前后血清L-17、FN-y及NO水平比较53.4不良反应…6第4章讨论7结论.9参考文献10致谢.111第1章引言流感是一种以急性高热、乏力、头痛、肌肉酸痛等为特征的急性呼吸道传染病，是一种极具传染性的疾病，可在人多的场所如校园等处迅速传播。患者在咳嗽、打喷嚏的时候，会将携带有病毒的水滴（也就是具有传染性的水滴）向空中飘散，距离