某院细菌耐药性监测结果与分析

某院细菌耐药性监测结果与分析摘要目的：为临床治疗和制定医院感染控制措施提供依据，监测和分析临床分离病原菌对常用抗菌药物的敏感性和耐药性。方法：对临床分离菌株采用回顾性调查方法进行统计，对病原微生物进行化验及痰液、尿液等标本的药敏试验，分析其药敏结果。结果：共检出3307株（真菌除外）非重复病原菌株，其中多重耐药菌1840株(55.64%)；病原菌来源以痰、尿为主：检出病原菌最多的为50-69岁患者：被检出病原菌最多的3个科室分别为神经二科、呼吸内科和神经一科：对四环素类替加环素高度敏感有肺炎克雷伯菌及其多重耐药菌ESBLs、CRKPN:对氨基糖苷类阿米卡星高度敏感有铜绿假单胞菌及其多重耐药菌CRPAE:奇异变形杆菌及其多重耐药菌ESBLs.均对碳青霉烯类美罗培南高度敏感，而其CRE则对所有类型抗生素均不敏感：对四环素类替加环素、米诺环素高度敏感的是鲍曼不动杆菌及其多重耐药菌CRAB:大肠埃希菌对碳青霉烯类有很高的敏感性，而其多重耐药菌ESBLs对大部分抗生素都具有敏感性：金黄色葡萄球菌100%敏感于糖肽类、利福霉素类，其多重耐药菌MRAS完全耐药于青霉素类。结论：该院细菌耐药形势严峻，合理使用抗菌药物必须进一步规范。【关键词】细菌耐药性：检测：抗菌药物：合理使用AbstractObjective:To provide a basis for clinical treatment and formulation of hospital infection controlmeasures,and to monitor and analyze the sensitivity and drug resistance of clinically isolatedpathogens to commonly used antibiotics.Methods The clinical isolates were statisticallyanalyzed by retrospective investigation.The pathogenic microorganisms were tested and thedrug sensitivity test of sputum,urine and other specimens was carried out to analyze the drugsensitivity results.Results A total of 3307 non-repetitive pathogenic strains except fungiwere detected,of which 1840 (55.64 %)were multidrug-resistant bacteria.The source ofpathogenic bacteria was mainly sputum and urine.The most pathogenic bacteria were detected inpatients aged 50-69 years.The three departments with the most detected pathogens were thesecond department of neurology,respiratory medicine and the first department of neurology.Klebsiella pneumoniae and its multi-drug resistant bacteria ESBLs and CRKPN were highlysensitive to tetracycline tigecycline.Highly sensitive to aminoglycoside amikacin Pseudomonasaeruginosa and its multi-drug resistant bacteria CRPAE proteus mirabilis and its multi-drugresistant bacteria ESBLs are highly sensitive to carbapenem meropenem,while its CRE is notsensitive to all types of antibiotics.Acinetobacter baumannii and its multi-drug resistant bacteriaCRAB were highly sensitive to tetracycline tigecycline and minocycline.Escherichia coli has ahigh sensitivity to carbapenems,and its multi-drug resistant bacteria ESBLs are sensitive to mostantibiotics.Staphylococcus aureus was 100%sensitive to glycopeptides and rifamycins,and itsmulti-drug resistant bacteria MRAS was completely resistant to penicillins.Conclusion Thesituation of bacterial resistance in this hospital is severe,and the rational use of antibiotics mustbe further standardized.Keywords bacterial resistance detection antibiotics rational use女目录第-章引言…1第二章资料与方法.12.1资料来源…12.2研究方法EEEEEEEEEEE22.2.1仪器和试剂2.2.2结果判读..22.2.3多重耐药菌判断」2第三章结果与分析.…23.1病原菌检出情况…23.1.1主要病原菌检出情况23.1.2检出病原菌标本分布3.1.3病原菌检出年龄分布EEEEEEEEEEEEEEEE43.14病原菌检出科室分布.43.1.5多重耐药菌检出情况63.1.6多重耐药菌标本分布…63.1.7主要多重耐药菌检出年龄分布73.1.8主要多重耐药菌科室分布情况73.2耐药性分析83.2.1主要病原菌的耐药性情况.83.2.2多重耐药菌的耐药率.11第四章讨论144.1病原菌的检出、标本分布、年龄分布及科室分布及耐药性情况…144.2多重耐药菌有关情况.…15第五章结论.15参考文献.16综述….18致谢28个人简历…29Ⅲ