重组牛碱性成纤维细胞生长因子原液生产车间工艺设计

Process design of production plant of recombinant bovine basicfibroblast growth factor stock solutionAbstractRecombinant bovine basic fibroblast growth factor(RB bFGF)is a kind of drug for acuteand chronic ulcer,trauma and other symptoms.It can stimulate the growth of mesoderm andneuroectoderm cells,such as fibroblasts,vascular endothelial cells,corneal cells,epithelialcells,nerve cells,muscle cells,bone cells,etc.it has a wide range of biological activities.Inthe daily life,it is often used in the beauty industry and treatment of various ulcers,wounds,burns,etc.,which can significantly shorten the wound healing cycle.It has a good marketprospect.The design mainly includes:according to fermentation and purification process,production process selection,selection of equipment required for production,cost estimation,material balance,design of production workshop and drawing of CAD drawings,etc.Thedesign of the workshop conforms to GMP standard and appropriate innovation,realizes theseparation of people and materials,ensures the production efficiency of the workshop,effectively avoids pollution and cross pollution,and facilitates the clean operation andmaintenance of the workshop.Stabilize the production quality while reducing the cost as faras possible,ensure the economic benefit of the workshopKeywords:Recombinant bovine basic fibroblast growth factor;Equipment selection;Material balance;CAD drawing;Workshop design