慢性乙肝患者血清腺苷脱氨酶、铜蓝蛋白水平与肝细胞损伤程度的关系

Relationship between serum adenosine deaminase,ceruloplasminand the level of hepatocyte injury in patients with chronic hepatitis BAuthor:Jian FuTutor:Qing ZhengAbstract Objective:To discuss the comrelation between serum ceruloplasmin (CER)and adenosine deaminase (ADA)levels and the degree of hepatocyte damage in patients withchronic liver disease.Methods:The clinical diagnosis was consistent with the 117 cases of"Viral Hepatitis Prevention Program"revised by the National Conference on Viral Hepatitis in2000.According to the classification criteria,75 cases were divided into chronic hepatitis B group;25 cases of hepatitis cirrhosis group;primary liver cancer group In 17 cases,42 healthy peopleaged 20-65 years were selected as the nommal control group.The levels of CER and ADA in eachgroup were determined by immunoturbidimetric assay and peroxidase assay,respectively,and thecorrelations between serum CER and ADA concentrations and liver cell damage in differentgroups were analyzed.Results:During the progression of chronic hepatitis to liver cimrhosis andliver cancer,ADA levels gradually increased:normal control group>chronic hepatitisgroup>hepatitis cirhosis group>primary liver cancer group,the difference was statisticallysignificant(P<0.01).The levels of serum CER in patients with chronic hepatitis B and cirrhosiswere significantly lower than those in patients with primary liver cancer (P<0.01).CONCLUSIONS:Chronic hepatitis B -liver cirrhosis-liver cancer disease progression,liver cell damage is a gradual evolution During this process,the level of serum ADA graduallyincreased,indicating that the degree of liver damage gradually increased,and the reserve,synthesis and decomposition functions gradually decreased.Therefore,real-time effectivemonitoring of serum ADA levels in patients with chronic liver disease has a high clinical value inthe treatment and prognosis of the disease,and combined detection of ADA and CER is conduciveto the identification and screening of cirrhosis and primary liver cancer.[Key words]:Chronic liver disease;Ceruloplasmin;Ferritin