年产260吨螺旋霉素的发酵车间设计

北京理工大学珠海学院2020届本科毕业设计Design of Fermentation Workshop with Annual Output of 260Tons of SpiramycinAbstractSpiramycin is a 16-membered macrolide antibiotic,widely distributed in the body,has astrong antibacterial effect in vivo,can effectively inhibit the growth and metabolism of drug-resistant bacteria such as penicillin,chloramphenicol.The toxic and side effects are much lowerthan those of erythromycin,and the post-antibiotic effect (PAE)effect produced by takingspiramycin is more durable.It is worth mentioning that spiramycin is currently the onlyantibacterial drug that can be used to treat cryptosporidium diarrhea.Studies have shown thatthe combination of spiramycin and other antibacterial drugs can expand the antibacterialspectrum and reduce the occurrence of drug resistance.The current spiramycin fermentationprocess is relatively mature.This topic mainly optimizes the design of the spiramycinfermentation plant,applies a more energy-efficient air pretreatment system,and improves theapplication of automated control in the fermentation plant to improve product quality andeconomy.Labor costs.This design is expected to be used in the fermentation workshop with anannual output of 260 tons of spiramycin.Key words:Spiramyc in;fermentation workshop;optimization;automation